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ECDC - COVID-19 testing strategies and objectives

European Centre for Disease Prevention and ControlImplementation of objective-driven and sustainable testing strategies for COVID-19 supports the overall public health response to the pandemic and helps mitigate its impact on vulnerable...

ECDC - Baseline projections of COVID-19 in the EU/EEA and the UK: update

European Centre for Disease Prevention and ControlFollowing widespread transmission of SARS-CoV-2 in European Union (EU)/European Economic Area (EEA) countries and the United Kingdom (UK) over several weeks, the COVID-19 epidemic reached a peak...

AMP - Case Series of 103 Children with SARS-CoV-2 Infection in Portugal

Acta Médica PortuguesaThe North Lisbon University Hospital Center was activated for referral of SARS-CoV-2 infected patients on the 11th March 2020. The aim of this study is to describe the experience at the Department of Pediatrics in the...

BMJ - Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

British Medical JournalInternational Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study (performed by the ISARIC Coronavirus Clinical...

JAMA - COVID-19 and the Path to Immunity

JAMA NETWORKThe emergence of adaptive immunity in response to the novel Betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurs within the first 7 to 10 days of infection. Understanding the key features and...

JAMA - Reassuring the Public and Clinical Community About the Scientific Review and Approval of a COVID-19 Vaccine

JAMA NETWORKPublic perception of the review of medications and vaccines for coronavirus disease 2019 (COVID-19) has become enmeshed in politics. The pressure on the US Food and Drug Administration (FDA) and Commissioner Stephen Hahn, MD, to...

WHO - Considerations for school-related public health measures in the context of COVID-19

World Health OrganizationCountries around the world are taking broad public health and social measures (PHSM), including closure of schools, to prevent the spread of the SARS-CoV-2 virus, which causes COVID-19.1 This Annex examines considerations...

WHO - Antigen-detection in the diagnosis of SARS-CoV-2 infection using rapid immunoassays

World Health OrganizationA new technology for COVID-19 detection has become available that is much simpler and faster to perform that currently-recommended nucleic acid amplification tests (NAAT), like PCR. This method relies on direct detection...

AMP - SARS-CoV-2 Pandemic: Should Children Wear Masks?

Acta Médica Portuguesa

Carta o editor aborda a especificidade dos diferentes tipos de máscaras.

The Lancet - Azithromycin in addition to standard of care versus standard of care alone in the treatment of patients admitted to the hospital with severe COVID-19 in Brazil (COALITION II): a randomise

The LancetThe efficacy and safety of azithromycin in the treatment of COVID-19 remain uncertain. We assessed whether adding azithromycin to standard of care, which included hydroxychloroquine, would improve clinical outcomes of patients admitted...

The Lancet - Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia

The LancetWe developed a heterologous COVID-19 vaccine consisting of two components, a recombinant adenovirus type 26 (rAd26) vector and a recombinant adenovirus type 5 (rAd5) vector, both carrying the gene for severe acute respiratory syndrome...

JAMA - Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 - A Meta-analysis

JAMA NETWORK

Is administration of systemic corticosteroids associated with reduced 28-day mortality in critically ill patients with coronavirus disease 2019 (COVID-19)?

JAMA - Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 - The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

JAMA NETWORKDoes intravenous hydrocortisone, administered either as a 7-day fixed-dose course or restricted to when shock is clinically evident, improve 21-day organ support–free days (a composite end point of in-hospital mortality and the...

JAMA - Effect of Dexamethasone on Days Alive and Ventilator-Free in Patients With Moderate or Severe Acute Respiratory Distress Syndrome and COVID-19 The CoDEX Randomized Clinical Trial

JAMA NETWORKIn patients with coronavirus disease 2019 (COVID-19) and moderate or severe acute respiratory distress syndrome (ARDS), does intravenous dexamethasone plus standard care compared with standard care alone increase the number of days...

JAMA - Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19 A Randomized Clinical Trial