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ECDC - Risk related to the spread of new SARS-CoV-2 variants of concern in the EU/EEA – first update

European Centre for Disease Prevention and ControlViruses constantly change through mutation and variations in the SARS-CoV-2 virus, due to evolution and adaptation processes, have been observed worldwide. While most emerging mutations will not...

WHO - Interim recommendations for use of the Pfizer–BioNTech COVID-19 vaccine, BNT162b2, under Emergency Use Listing

World Health Organization

This interim guidance has been developed based on the advice issued by the Strategic Advisory Group of Experts on Immunization (SAGE) at its 5 January 2021 extraordinary meeting.

AMP - Influenza Vaccination in Patients with Cardiovascular Disease Under 65 in the COVID-19 Era

Acta Médica Portuguesa

Sabemos que a vacinação contra o vírus influenza nos doentes com patologia cardiovascular reduz significativamente o número de eventos cardiovasculares major e a mortalidade cardiovascular.

THE LANCET - 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

The LancetThe long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the...

NEJM - Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

The New England Journal of MedicineTherapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because...

NICE - COVID-19 rapid guideline: managing the long-term effects of COVID-19

National Institute for Health and Care ExcellenceThis guideline covers identifying, assessing and managing the long-term effects of COVID-19, often described as ‘long COVID’. It makes recommendations about care in all healthcare settings for...

NEJM - Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

The New England Journal of MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting coronavirus disease 2019 (Covid-19) have afflicted tens of millions of people in a worldwide pandemic. Safe and effective...

NEJM - Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

The New England Journal of MedicineVaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle–encapsulated mRNA-based vaccine...

ECDC - Risk Assessment: Risk related to spread of new SARS-CoV-2 variants of concern in the EU/EEA

European Centre for Disease Prevention and ControlViruses constantly change through mutation, and so the emergence of new variants is an expected occurrence and not in itself a cause for concern; SARS-CoV-2 is no exception. A diversification of...

NEJM - Tocilizumab in Patients Hospitalized with Covid-19

The New England Journal of MedicineThe efficacy of tocilizumab was tested in a randomized, controlled trial involving patients with Covid-19 who had fever, pulmonary infiltrates, or a need for supplemental oxygen. The treatment had no significant...

INFARMED - COVID-19 – Operacionalização da utilização dos Testes Rápidos de Antigénio (TRAg)

Autoridade Nacional do Medicamento e Produtos de SaúdeNo contexto da atual situação epidemiológica provocada pelo novo coronavírus SARS-CoV-2 e pela doença COVID-19, o Ministério da Saúde tem vindo a adotar e implementar medidas com vista à...

WHO - Evidence to recommendations for COVID-19 vaccines: Evidence framework

World Health OrganizationAs market-authorized COVID-19 vaccines become available, specific recommendations for the use of these vaccines will need to be issued. This SAGE evidence framework is intended to offer guidance for considering data...

ECDC - Overview of COVID-19 vaccination strategies and vaccine deployment plans in the EU/EEA and the UK

European Centre for Disease Prevention and ControlThis report provides an initial overview of the national COVID-19 vaccination strategies and vaccine deployment plans in the countries of the European Union and European Economic Area (EU/EEA) and...

NEJ - Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine