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WHO - Corticosteroids for COVID-19

World Health OrganizationThis guidance was developed in collaboration with the non-profit Magic Evidence Ecosystem Foundation (MAGIC), which provided methodologic support to develop and disseminate living guidance for COVID-19 drug treatments. We...

JAMA - Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 A Randomized Clinical Trial

JAMA NETWORK

Does remdesivir provide a benefit on clinical status for patients hospitalized with moderate coronavirus disease 2019 (COVID-19) pneumonia?

THE LANCET - Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

The LancetSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) region of the genome have been detected in Singapore and other countries. We investigated the...

THE LANCET - Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study

The LancetTocilizumab, a monoclonal antibody directed against the interleukin-6 receptor, has been proposed to mitigate the cytokine storm syndrome associated with severe COVID-19. We aimed to investigate the association between tocilizumab...

BMJ - Management of post-acute covid-19 in primary care

British Medical JournalPost-acute covid-19 (“long covid”) seems to be a multisystem disease, sometimes occurring after a relatively mild acute illness. Clinical management requires a whole-patient perspective. This article, intended for...

NEJM - Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

The New England Journal of MedicineHydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is limited.

NEJM - Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

The New England Journal of MedicineCoronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death.

THE LANCET - Tocilizumab in patients with severe COVID-19: a retrospective cohort study

No therapy is approved for COVID-19 pneumonia. The aim of this study was to assess the role of tocilizumab in reducing the risk of invasive mechanical ventilation and death in patients with severe COVID-19 pneumonia who received standard of care...

THE LANCET - Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study

The COVID-19 pandemic is challenging advanced health systems, which are dealing with an overwhelming number of patients in need of intensive care for respiratory failure, often requiring intubation. Prone positioning in intubated patients is...

JAMA - Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality

JAMA NetworkIn a retrospective cohort study of 4480 patients diagnosed as having COVID-19, prior ACEI/ARB use, compared with no use, was not significantly associated with mortality (adjusted hazard ratio, 0.83). In a nested case-control study of...

JAMA - Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure

JAMA NETWORKCritically ill patients with coronavirus disease 2019 (COVID-19) severely strained intensive care resources in New York City in April 2020. The prone position improves oxygenation in intubated patients with acute respiratory...

JAMA - Convalescent Plasma and COVID-19

JAMA NETWORK

Donated convalescent plasma may be beneficial to patients with severe coronavirus disease 2019 (COVID-19) to boost their ability to fight the virus.

JAMA - Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure A Systematic Review and Meta-analysis

JAMA NETWORK

What are the associations between noninvasive oxygenation strategies and outcomes among adults with acute hypoxemic respiratory failure?

JAMA - Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19 A Randomized Clinical Trial

JAMA NETWORKWhat is the effect of convalescent plasma therapy added to standard treatment, compared with standard treatment alone, on clinical outcomes in patients with severe or life-threatening coronavirus disease 2019 (COVID-19)?

NEJM - A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

The New England Journal of MedicineCoronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is observation and quarantine. Whether...

WHO - Corticosteroids for COVID-19

JAMA - Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19 A Randomized Clinical Trial

THE LANCET - Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

THE LANCET - Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study

BMJ - Management of post-acute covid-19 in primary care

NEJM - Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19

NEJM - Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

THE LANCET - Tocilizumab in patients with severe COVID-19: a retrospective cohort study

THE LANCET - Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study

JAMA - Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality

JAMA - Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure

JAMA - Convalescent Plasma and COVID-19

JAMA - Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure A Systematic Review and Meta-analysis

JAMA - Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and Life-threatening COVID-19 A Randomized Clinical Trial

NEJM - A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

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